Does J9021 require prior authorization?

Yes, J9021 requires prior authorization (high confidence). At least one active policy explicitly requires prior authorization.

What is the Medicare reimbursement rate for J9021?

Medicare facility rate: N/A. Non-facility rate: N/A. Work RVU: 0.00.

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`J9021`, Injection, asparaginase, recombinant, (rylaze), 0.1 mg

HCPCS/CPT

Prior Authorization

Prior Auth Required

At least one active policy explicitly requires prior authorization (high confidence)

Medicare Pricing

Work RVU

0.00

Facility

N/A

Non-Facility

N/A

Documentation Required

Procedure codes listed are for general reference and may not be all-inclusive.
Benefit coverage/reimbursement determinations must be based on the written coverage position in the Medical Policy, not on the presence or absence of listed codes.

Key Coverage Criteria

Medically necessary when the drug is FDA‑approved and administered in accordance with FDA labeling for an oncologic indication.
Medically necessary when the drug has an NCCN category 1, 2A, or 2B recommendation or is listed in the NCCN Drugs & Biologics Compendium.
Medically necessary when the drug is FDA‑approved and administered in accordance with FDA labeling for an oncologic indication.
Medically necessary when the drug has an NCCN category 1, 2A, or 2B recommendation or is listed in the NCCN Drugs & Biologics Compendium.
Oncology medications are medically necessary if (a) the drug is FDA-approved for the oncologic indication and used per FDA labeling, OR (b) the drug has an NCCN Category 1/2A/2B indication per NCCN Guidelines or NCCN Compendium.
Oncology medications may be considered medically necessary when the drug (a) is FDA-approved for an oncologic indication and used per FDA labeling, or (b) has NCCN Category 1/2A/2B recommendation per NCCN Guidelines or NCCN Compendium.

15 Active Policies

ARKBLUE-ASPARAGINE-SPECIFIC-ENZYMES-E-G-RYLAZE-ASPARLAS-677AF6A555, Asparagine Specific Enzymes (e.g., Rylaze, Asparlas, Oncaspar)

HEALTHPARTNERS-CC-ENTRY-247646, Asparaginase erwinia chrysanthemi (recombinant) - rywn (Rylaze) - Minnesota Health Care Programs

MULTI

MODA-RYLAZE-91EEC5264B, Rylaze (asparaginase Erwinia chrysanthemi (recombinant)-rywn)

HEALTHNET_OR-HNOR-ERWINIA-ASPARAGINASE-RYLAZE-CP-PHAR-301-3BD4BF2707, Erwinia Asparaginase (Rylaze); CP.PHAR.301

IBX-MEDICARE-ADVANTAGE-MA08-085K-85F20EFB22, Asparaginase Erwinia Chrysanthemi (recombinant)-rywn (Rylaze)

IBX-COMMERCIAL-08-01-35K-7CEE4B475E, Asparaginase Erwinia Chrysanthemi (recombinant)-rywn (Rylaze)

BCBSMT-RX502.061, Oncology Medications

BCBSNM-RX502.061, Oncology Medications

EVICORE-HPLAN-CIGNA-729A536F50C8, Q3 - 2026 Cigna MedOnc Master Drug List.pdf

BCBSOK-RX502.061, Oncology Medications

EVICORE-HPLAN-HEALTH_PARTNERS_PLANS-4BC80209CCC5, Q3 - 2026 Jefferson Health Plans MedOnc Master Drug List

AMERIHEALTH-COMMERCIAL-08-01-35K-097C2E7FFE, Asparaginase Erwinia Chrysanthemi (recombinant)-rywn (Rylaze)

AMERIHEALTH-MEDICARE-ADVANTAGE-MA08-085K-54F1318C78, Asparaginase Erwinia Chrysanthemi (recombinant)-rywn (Rylaze)

BCBSTN-dfaa9e93f4, Asparaginase Erwinia chrysanthemi (recombinant)-rywn (Rylaze)

BCBSIL-RX502.061, Oncology Medications

`J9021`, Injection, asparaginase, recombinant, (rylaze), 0.1 mg

Prior Authorization

Medicare Pricing

Documentation Required

Key Coverage Criteria

15 Active Policies

Related Codes

Have a follow-up question?

J9021, Injection, asparaginase, recombinant, (rylaze), 0.1 mg

Prior Authorization

Medicare Pricing

Documentation Required

Key Coverage Criteria

15 Active Policies

Related Codes

Have a follow-up question?

`J9021`, Injection, asparaginase, recombinant, (rylaze), 0.1 mg