Does N48.6 require prior authorization?

No, N48.6 does not require prior authorization (high confidence). Covered without prior authorization.

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`N48.6`, Induration penis plastica

ICD-10-CM

Prior Authorization

No Prior Auth Required

Covered without prior authorization (high confidence)

Documentation Required

Diagnosis documentation: Dupuytren's contracture with a palpable cord OR Peyronie's disease with a palpable plaque.
Age documentation: Patient is 18 years of age or older.
Objective measurements: For Dupuytren's — documented contracture degree (>=20 degrees for initial therapy; >5 degrees for continuation); for Peyronie's — documented curvature degree (>=30 degrees at start for initial therapy; >=15 degrees remaining for continuation).
Documentation that the flexion deformity results in functional limitations (Dupuytren's).

Key Coverage Criteria

Dupuytren's contracture: Xiaflex is proven and medically necessary for the treatment of Dupuytren's contracture when all of the following criteria are met: For initial therapy, all of the following: Patient has diagnosis of Dupuytren's contracture with a palpable cord; and Patient is 18 years of age or older; and Xiaflex is prescribed and administered by a healthcare provider experienced in injection procedures of the hand and in the treatment of Dupuytren's contracture; and Documented contractu [...]
Dupuytren's contracture — continuation of therapy: For continuation of therapy, all of the following: Patient has previously received Xiaflex; and Documentation of positive clinical response to Xiaflex; and Treatment request is for at least one of the following: Metacarpophalangeal (MP) or proximal interphalangeal (PIP) contracture remains in affected cord since previous injection and the contracture is >5 degrees OR A different MP or PIP contracture will be injected and If two injections (two v [...]
Peyronie's disease: Xiaflex is proven and medically necessary for the treatment of Peyronie's disease when all of the following criteria are met: For initial therapy, all of the following: Patient has diagnosis of Peyronie's disease with both of the following: Palpable plaque; and Curvature deformity of greater than or equal to 30 degrees at the start of therapy and Patient is 18 years of age or older; and Xiaflex is prescribed and administered by a healthcare provider experienced in the treatme [...]
Peyronie's disease — continuation of therapy: For continuation of therapy, all of the following: Patient has previously received Xiaflex; and Documentation of positive clinical response to Xiaflex; and Last treatment was at least 6 weeks ago; and Documented curvature deformity of >= 15 degrees remaining since last treatment cycle; and Patient has received less than 4 treatment cycles [i.e., less than 8 injections (2 injections per cycle)]; and Xiaflex dosing is in accordance with the U.S. [...]
FDA indication (informational): "Xiaflex is a combination of bacterial collagenases indicated for the treatment of adult patients with Dupuytren's contracture with a palpable cord and the treatment of adult men with Peyronie's disease with a palpable plaque and curvature deformity of at least 30 degrees at the start of therapy."
Corpora cavernosography and cavernosal injection diagnostic procedures (CPT 74445, 54230-54235) when selection criteria are met.

3 Active Policies

AETNA-CPB-0007, Erectile Dysfunction and Peyronie's Disease

AETNA-CPB-0229, Iontophoresis

UHC-POL-xiaflex, Xiaflex (Collagenase Clostridium Histolyticum)

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N48.6, Induration penis plastica