Does S3852 require prior authorization?

No, S3852 does not require prior authorization (high confidence). Code is covered without prior authorization.

What is the Medicare reimbursement rate for S3852?

Medicare facility rate: N/A. Non-facility rate: N/A. Work RVU: 0.00.

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`S3852`, Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease

HCPCS/CPT

Prior Authorization

No Prior Auth Required

Code is covered without prior authorization (high confidence)

Medicare Pricing

Work RVU

0.00

Facility

N/A

Non-Facility

N/A

Documentation Required

Discern / NeuroDiagnostics: peripheral skin samples are collected via a standard 2-3mm punch biopsy taken from the bicep/forearm area (procedure description/collection requirement).
MindX Blood Test - Memory/Alzheimer's: 'The test is available by prescription only.' (requires ordering provider prescription) and is 'indicated for middle aged or elderly patients presenting signs of forgetfulness, depression, periods of high stress, and a family history of dementia.'

General (implicit): many biomarker studies referenced required clinical characterization (e.g., clinical diagnosis of AD/MCI, neuropsychological testing, MMSE, Clinical Dementia Rating), APOE genotype status, imaging (MRI, PET), and CSF collection via lumbar puncture — meaning interpretation in research/clinical studies depends on paired clinical and imaging/CSF data.

Key Coverage Criteria

Lumbar puncture (CSF testing) to confirm presence of elevated phosphorylated tau (P-tau) and/or elevated total tau (T-tau) and reduced beta amyloid-42 (Aβ42) or a low Aβ42/Aβ40 ratio as determined by the lab assay detected in cerebrospinal fluid (CSF) for the assessment of mild cognitive impairment (MCI) when Alzheimer's disease (AD) is suspected.
Brain magnetic resonance imaging (MRI) for persons on aducanumab-avwa (Aduhelm) or lecanemab-irmb (Leqembi) therapy for the following indications: (a) within one year prior to initiating aducanumab or lecanemab therapy to indicate AD, or (b) to evaluate for evidence of amyloid-related imaging abnormalities (ARIA) prior to the 5th, 7th, 9th, and 12th aducanumab dose or prior to the 5th, 7th, and 14th lecanemab dose (see CPB 0996 and CPB 1026 for details).
Genetic mutation testing for APP, PSEN1, or PSEN2 for members with MCI or mild AD dementia who are less than 50 years of age and who are being considered for enrollment in a clinical trial of aducanumab (Aduhelm) or lecanemab (Leqembi).
Amyloid PET scan indications are referenced (see CPB 0071 - Positron Emission Tomography (PET)) — amyloid PET is handled under CPB 0071.
Alzheimer's disease (G30.0 - G30.9)
Neurology (mild cognitive impairment) — CSF B-amyloid 1-42 and 1-40 chemiluminescence enzyme immunoassay reported as positive/likely positive/negative (0358U) — covered if selection criteria are met

5 Active Policies

CARELON-genetic-testing-for-inherited-conditions-2025-09-20-updated-2026-07-01, Genetic Testing for Inherited Conditions

CARELON-pharmacogenetic-testing-2026-06-14-updated-2026-07-01, Pharmacogenetic Testing

AETNA-CPB-0349, Alzheimer's Disease Tests

AMBETTER-CG-Epilepsy-Neurodegen-Neuromusc-DO-2025.1, Concert Genetic Testing: Epilepsy, Neurodegenerative, and Neuromuscular Conditions

REGENCE-GT01, Genetic Testing for Alzheimer's Disease

`S3852`, Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease

Prior Authorization

Medicare Pricing

Documentation Required

Key Coverage Criteria

5 Active Policies

Related Codes

Have a follow-up question?

S3852, Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease

Prior Authorization

Medicare Pricing

Documentation Required

Key Coverage Criteria

5 Active Policies

Related Codes

Have a follow-up question?

`S3852`, Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease