About this policy
CMS National Coverage Determination | ncd_id=319 | manual_section=110.20 | coverage_level_code=3 | national_coverage_type=True | under_review=True | lab_ncd=False
Coverage indications
B. Nationally Covered Indications N/A C. Nationally Non-Covered Indications Effective for services performed on and after March 20, 2007, the Centers for Medicare & Medicaid Services determines that the use of osmotic BBBD is not reasonable and necessary when it is used as part of a treatment regimen for brain tumors. D. Other This NCD does not alter in any manner the coverage of anti-cancer chemotherapy. (This NCD last reviewed March 2007.)
Documentation requirements
Item/Service Description: A. General The blood brain barrier (BBB) of the central nervous system is characterized by tight junctions between vascular endothelial cells, which prevent or impede various naturally occurring and synthetic substances (including anti-cancer drugs) from entering brain tissue. The BBB may be partly responsible for the poor efficacy of chemotherapy for malignant primary or metastatic brain tumors. The BBBD is the disruption of the tight junctions between the endothelial cells that line the capillaries in the brain accomplished by osmotic disruption, bradykinin or irradiation. Theoretically, disruption of the BBB may, in the treatment of brain tumors, increase the concentration of chemotherapy drugs delivered to the tumor and may prolong the drug-tumor contact time. Osmotic disruption of the BBB is the most common technique used. Chemotherapeutic agents are given in conjunction with barrier disruption. The BBBD process includes all items and services necessary to perform the procedure, including hospitalization, monitoring, and repeated imaging procedures. Revision History: 04/2007 - Effective for claims with dates of service on and after March 20, 2007, CMS determines that the use of osmotic blood brain barrier disruption is not reasonable and necessary when it is used as part of a treatment regimen for brain tumors. This NCD does not alter in any manner the coverage of anti-cancer chemotherapy. Effective date: 03/20/2007. Implementation date: 05/07/2007 ( TN67 ) Benefit Categories: 33 - Incident to a physician's professional Service; 35 - Inpatient Hospital Services Transmittal: transmittal_number=67 | transmittal_issue_date=2007-04-06 | change_request_number=5530
Codes in this policy
Code numbers and each code’s status as the policy records it. CPT code descriptions are left out of this page, as are the passages that cite CPT codes; the official document has them.
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