Biomarkers Overview
JH · Effective Oct 1, 2015
24 active Medicare policies list 81422, and 8 commercial payer policies list it. See each policy's status for the code and its official source. Listing a code is not a coverage decision: read each policy’s source for the requirements that apply.
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JH · Effective Oct 1, 2015
JL · Effective Oct 1, 2015
J9 · Effective Jul 17, 2023
JH · Effective Jul 17, 2023
JL · Effective Jul 17, 2023
J15 · Effective Oct 1, 2015
JE · Effective Oct 1, 2015
JF · Effective Oct 1, 2015
JJ · Effective Oct 1, 2015
8 policies from 7 payers
Summary of the payer’s published policy. Not a coverage determination — confirm with the payer before submitting.
| Policy | Effective | Status of 81422 |
|---|---|---|
| Prenatal Screening Using Cell Free Dna | Sep 19, 2026 | Covered |
| Prenatal Screening Using Cell Free Dna | Sep 20, 2025 | Covered |
| Policy | Effective | Status of 81422 |
|---|---|---|
| Maternal Biomarker Screening for Fetal Conditions | May 5, 2023 | Covered |
JM · Effective Oct 1, 2015
J5 · Effective Feb 16, 2017
J8 · Effective Feb 16, 2017
J9 · Effective Oct 1, 2015
J6 · Effective Oct 1, 2015
JK · Effective Oct 1, 2015
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
J5 · Effective Jul 1, 2026
JL · Effective Jul 1, 2026
J9 · Effective Jul 1, 2026
J6 · Effective Jul 15, 2026
| Policy | Effective | Status of 81422 |
|---|
| Concert Genetic Testing: Prenatal Screening | Not recorded | Referenced |
|---|
| Policy | Effective | Status of 81422 |
|---|---|---|
| Chromosomal Microarray Analysis (CMA) or Copy Number Analysis for the Genetic Evaluation of Patients with Developmental Delay, Intellectual Disability, Autism Spectrum Disorder, or Congenital Anomalies | Aug 1, 2026 | Covered |
| Policy | Effective | Status of 81422 |
|---|---|---|
| Cell-Free Fetal DNA Testing | Oct 1, 2026 | Covered |
| Policy | Effective | Status of 81422 |
|---|---|---|
| Cell-Free Fetal DNA Testing | Oct 1, 2026 | Covered |
| Policy | Effective | Status of 81422 |
|---|---|---|
| Cell-Free Fetal DNA Testing | Oct 1, 2026 | Covered |