Biomarkers Overview
JH · Effective Oct 1, 2015
33 active Medicare policies list 81451, and 7 commercial payer policies list it. See each policy's status for the code and its official source. Listing a code is not a coverage decision: read each policy’s source for the requirements that apply.
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JH · Effective Oct 1, 2015
JL · Effective Oct 1, 2015
J9 · Effective Jul 17, 2023
JH · Effective Jul 17, 2023
JL · Effective Jul 17, 2023
J6 · Effective Aug 1, 2018
JK · Effective Aug 1, 2018
J15 · Effective Oct 1, 2015
JE · Effective Oct 1, 2015
7 policies from 7 payers
Summary of the payer’s published policy. Not a coverage determination — confirm with the payer before submitting.
| Policy | Effective | Status of 81451 |
|---|---|---|
| Tumor Markers | Mar 5, 2024 | Covered |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Cigna Comprehensive Code List | Mar 7, 2026 | Prior auth required |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Genomic and Molecular Biomarker Testing for Cancer | Sep 23, 2026 |
JF · Effective Oct 1, 2015
JJ · Effective Oct 1, 2015
JM · Effective Oct 1, 2015
J5 · Effective Feb 16, 2017
J8 · Effective Feb 16, 2017
J15 · Effective Feb 10, 2020
JE · Effective May 17, 2020
JF · Effective May 17, 2020
JJ · Effective Feb 10, 2020
JM · Effective Feb 10, 2020
J5 · Effective Feb 9, 2020
J8 · Effective Feb 9, 2020
J9 · Effective Oct 1, 2015
J6 · Effective Apr 1, 2026
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
J5 · Effective Jul 1, 2026
National · Effective Oct 1, 2026
National · Effective Sep 24, 2026
J5 · Effective Oct 1, 2026
National · Effective Oct 1, 2026
JL · Effective Jul 1, 2026
J9 · Effective Jul 1, 2026
| Covered |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Genetic Testing for Myeloid Neoplasms and Leukemia | Jun 1, 2026 | Covered |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Molecular Oncology Testing for Hematologic Cancer Diagnosis, Prognosis, and Treatment Decisions | Aug 1, 2026 | Covered |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Molecular Oncology Testing for Hematologic Cancer Diagnosis, Prognosis, and Treatment Decisions | Aug 1, 2026 | Covered |
| Policy | Effective | Status of 81451 |
|---|---|---|
| Molecular Oncology Testing for Hematologic Cancer Diagnosis, Prognosis, and Treatment Decisions | Aug 1, 2026 | Covered |