Biomarkers Overview
JH · Effective Oct 1, 2015
30 active Medicare policies list 81464, and 6 commercial payer policies list it. See each policy's status for the code and its official source. Listing a code is not a coverage decision: read each policy’s source for the requirements that apply.
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JH · Effective Oct 1, 2015
JL · Effective Oct 1, 2015
J9 · Effective Jul 17, 2023
JH · Effective Jul 17, 2023
JL · Effective Jul 17, 2023
J15 · Effective Oct 1, 2015
JE · Effective Oct 1, 2015
JF · Effective Oct 1, 2015
JJ · Effective Oct 1, 2015
6 policies from 5 payers
Summary of the payer’s published policy. Not a coverage determination — confirm with the payer before submitting.
| Policy | Effective | Status of 81464 |
|---|---|---|
| Genetic Liquid Biopsy in the Management of Cancer and Cancer Surveillance | Aug 22, 2026 | Covered |
| Genetic Liquid Biopsy in the Management of Cancer and Cancer Surveillance | Jun 14, 2026 | Covered |
| Policy | Effective | Status of 81464 |
|---|---|---|
| Tumor Markers | Mar 5, 2024 | Covered |
JM · Effective Oct 1, 2015
J5 · Effective Feb 16, 2017
J8 · Effective Feb 16, 2017
J15 · Effective Jul 27, 2020
JE · Effective Dec 26, 2022
JF · Effective Dec 26, 2022
JJ · Effective Feb 3, 2020
JM · Effective Feb 3, 2020
J5 · Effective Mar 15, 2020
J8 · Effective Mar 15, 2020
J9 · Effective Oct 1, 2015
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
National · Effective Jul 1, 2026
J5 · Effective Jul 1, 2026
National · Effective Jul 1, 2025
National · Effective Jul 1, 2025
J5 · Effective Jul 1, 2025
National · Effective Feb 5, 2026
JL · Effective Jul 1, 2026
J9 · Effective Jul 1, 2026
| Policy | Effective | Status of 81464 |
|---|---|---|
| Concert Genetic Testing Oncology: Solid Tumor Molecular Diagnostics | Not recorded | Referenced |
| Policy | Effective | Status of 81464 |
|---|---|---|
| Cigna Comprehensive Code List | Mar 7, 2026 | Prior auth required |
| Policy | Effective | Status of 81464 |
|---|---|---|
| Circulating Tumor DNA and Circulating Tumor Cells for Management (Liquid Biopsy) of Solid Tumor Cancers | Jul 1, 2026 | Covered |